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Overview

The Thermo Scientific Orbitrap Exploris 120 mass spectrometer accelerates your route to both qualitative and quantitative assurance, whether in method development or routine testing. Its unparalleled capability to consistently provide highly sensitive and precise data, coupled with a user-friendly design, sets a new standard to be applied in both non-targeted and targeted projects.

 Features

• • • Enhance resolution and speed with capabilities of up to 120,000 resolution and 22 Hz scan speed.
    • Enable MS/MS precursor ion selection with exceptional transmission efficiency across a wide range from m/z 40 to 3,000.
    • Perform alternating positive and negative ion scans within a single injection in approximately 1.4 Hz.
    • Achieve sub-parts per million (sub-ppm) mass accuracy.

Software

• Xcalibur – Targeted quantitation.
• FreeStyle – Chromatogram display, mass spectra display, m/z possible formulas, formulas expected from mass spectra.
• Tracefinder – High-throughput screening and quantitation with intuitive set of acquisition and data processing tools.
• Compound Discoverer – Streamlines compound identification, facilitates comparative analyses, and offers extensive filtering options, along with powerful data visualization tools tailored for small molecule analysis.
• Proteome Discoverer – Efficiently manages datasets for statistical analyses, biological annotation, data interpretation, simplifying the identification and quantification of proteins in complex biological samples across a diverse range of proteomics workflows.
• BioPharma Finder – Access workflows that facilitate comprehensive interpretation, data visualization and biotherapeutic characterization include intact mass analysis, peptide mapping, oligonucleotide analysis, top- and middle-down analysis or Multi-Attribute Method (MAM) workflows.

Support

Email Githal Arachchige for all enquiries related to the Thermo Scientific Orbitrap Exploris 120 mass spectrometer.

Considerations

Chromatography columns are not included; users are required to provide their own column for use with this instrument. De novo assay setup is also available and should be coordinated with the School of Chemical Sciences mass spectrometry technical team for further discussion and assistance.

Limitations

Ideal for small molecule peptides, this instrument may not be suitable for analyzing proteins and large compounds unless they have undergone enzymatic digestion.

Cost

Small Molecule / Peptide Identification Mon-Fri 08:00 AM – 05:00 PM (UOA: $10.00/hr, Outside Academic: $48.00/hr, Outside Commercial: $240.00/hr)

Chromatography – Per Hour Sun-Sat 12:00 AM – 12:00 AM (UOA: $10.00/hr, Outside Academic: $48.00/hr, Outside Commercial: $240.00/hr)

Eligibility

Available for all Auckland University students and staff. External and commercial users are also eligible to use the equipment.

Access Requirements

The LC-MS facility is housed on the Main Campus in the School of Chemical Sciences (Building 301, room 514).

Training

Training can be booked through the iLab booking system.

Booking

Contact Githal Arachchige for Booking.